May 24, 2023

Therapeutic Effects of Cannabis and Cannabinoids

Cannabis sativa has a long history as a medicinal plant, likely dating back more than two millennia

Cannabis sativa has a long history as a medicinal plant, likely dating back more than two millennia (Russo et al., 2007). It was available as a licensed medicine in the United States for about a century before the American Medical Association removed it from the 12th edition of the U.S. Pharmacopeia (IOM, 1999). In 1985, pharmaceutical companies received approval to begin developing Δ9-tetrahydrocannabinol (THC) preparations—dronabinol and nabilone—for therapeutic use, and as a result, cannabinoids were reintroduced into the armamentarium of willing health care providers (Grotenhermen and Müller-Vahl, 2012).

Cannabis and cannabinoids have been studied for their potential therapeutic effects in various medical conditions. Here are some of the potential therapeutic uses:

·      Pain Management: Cannabis and cannabinoids, such as THC and CBD, have shown promise in managing chronic pain, including neuropathic pain, cancer-related pain, and pain associated with conditions like multiple sclerosis and fibromyalgia.

·      Multiple Sclerosis (MS): Some research suggests that cannabis may help reduce muscle spasticity and improve mobility in individuals with MS.

·      Nausea and Vomiting: Cannabis-based medications have been used to alleviate nausea and vomiting caused by chemotherapy and other medical treatments.

·      Epilepsy: Certain cannabinoids, particularly CBD, have shown potential in reducing seizure frequency in some forms of epilepsy, such as Dravet syndrome and Lennox-Gastaut syndrome.

·      Mental Health Conditions: While the research is ongoing, cannabinoids like CBD have been investigated for their potential use in managing symptoms of mental health conditions such as anxiety, post-traumatic stress disorder (PTSD), and schizophrenia.

·      Sleep Disorders: As mentioned earlier, THC may have sedative effects and could potentially be used to aid sleep. However, more research is needed to fully understand its impact on sleep disorders.

·      Appetite Stimulation: Cannabis and cannabinoids have been used to increase appetite in conditions such as cancer and HIV/AIDS, where appetite loss is common.

·      It is important to note that the therapeutic effects of cannabis and cannabinoids are still being studied, and further research is needed to understand their efficacy, optimal dosage, and long-term effects. Additionally, the use of cannabis for medical purposes should always be done under the guidance of a healthcare professional.

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